| Fecha | Local | Visitante | Resultado |
|---|---|---|---|
| 13/03/25 18:45 | Athletic Club | AS Roma | 3:1 |
| 13/03/25 18:45 | Lazio Roma | Viktoria Pilsen | 1:1 |
| 13/03/25 18:45 | Olympiacos Piräus | FK Bodö/Glimt | 2:1 |
| 13/03/25 18:45 | Eintracht Frankfurt | Ajax Amsterdam | 4:1 |
| 13/03/25 21:00 | Tottenham | AZ Alkmaar | 3:1 |
| 13/03/25 21:00 | Manchester United | Real Sociedad de Fútbol | 4:1 |
| 13/03/25 21:00 | Olympique Lyon | FCSB Bukarest | 4:0 |
| 13/03/25 21:00 | Glasgow Rangers | Fenerbahçe SK | 3:4pen. |