| Fecha | Local | Visitante | Resultado |
|---|---|---|---|
| 20/02/25 18:45 | FK Bodö/Glimt | FC Twente Enschede | 5:2t.pro. |
| 20/02/25 18:45 | FCSB Bukarest | PAOK Salónica | 2:0 |
| 20/02/25 18:45 | Galatasaray Estanbul | AZ Alkmaar | 2:2 |
| 20/02/25 18:45 | AS Roma | FC Porto | 3:2 |
| 20/02/25 21:00 | RSC Anderlecht | Fenerbahçe SK | 2:2 |
| 20/02/25 21:00 | Ajax Amsterdam | Royale Union Saint-Gilloise | 1:2t.pro. |
| 20/02/25 21:00 | Real Sociedad de Fútbol | FC Midtjylland | 5:2 |
| 20/02/25 21:00 | Viktoria Pilsen | Ferencvaros Budapest | 3:0 |